After some more time in the cooker, python-route53 1.0 has landed onPyPi. This is a stand-alone Route 53 package, independent from the one in boto. The major hilights are:

• Python 2.7 and 3.x compatibility.
• Extremely simple API
• Powered by requests

Read the documentation, see the source, and yell at me on the issue tracker or Twitter.